The Ohio State University, OSU



Research Interest

The Lab and Personnel

Major Honors

Editor and Editorial Board


Positions Available

News Release


2019 2nd Conference on Biomotors, Virus Assembly, and Nanobiotechnology Applications

2017 1st Conference on Biomotors, Virus Assembly, and Nanobiotechnology Applications

2016 RNA Nanotechnology Conference

2015 Gordon Research Conference on RNA Nanotechnology

2013 International Conference of
RNA Nanotechnology and Therapeutics

2010 International Conference of RNA Nanotechnology and Therapeutics

A Chinese Poem Composed and Written by Peixuan Guo

An Oriental Music Concert Organized and Played by Peixuan Guo

2014 Chinese New Year Music Performed by Peixuan Guo

Dr. Peixuan Guo

Sylvan G. Frank Endowed Chair in Pharmaceutics and Drug Delivery Systems;

Director of Center for RNA Nanobiotechnology and Nanomedicine;
President of International Society of RNA Nanotechnology and Nanomedicine;
College of Pharmacy;
College of Medicine/Department of Physiology & Cell Biology;
Dorothy M. Davis Heart and Lung Research Institute (DHLRI).
Director, NIH/NCI Cancer Nanotechnology Platform Partnership Program:
  "RNA Nanotechnology for Cancer Therapy"
NIH Nanomedicine Development Center

Mailing Address: 912 Biomedical Research Tower (BRT), 460 W 12th Ave., Columbus, OH 43210, USA

Email: RNAnanocenter@osu.edu;

Phone: (614)293-2114 (Office), (614)293-2188 (Lab)

Administrative Associate: Lora McBride
phone: (614) 293-2147 (Office); email: mcbride.366@osu.edu



Latest News: Our paper "RNA Nanoparticles as Rubber for Compelling Vessel Extravasation to Enhance Tumor Targeting and for Fast Renal Excretion to Reduce Toxicity" by Chiran Ghimire, et al. is published in ACS Nano. Congratulations to everyone! (OSU CCC News Release and OSU College of Pharmacy News Release)


Journal Covers
(click to see larger image or view paper from Guo lab)

Cover image credit: Dr. Nils G. Walter


Reports on Research

Treating Cancer with RNA Nanotechnology:

Phi29 Nano-motor:######

Single-Molecule Study:####

Motor Nanopore:########

(NCI Report 1)
(NCI Report 2)

(Science Now)


(UC Health News )
(The News Record) (People's Daily Online


Stable RNA for Nanotechnology:

RNA polygons based on pRNA-3WJ:

RNA nanoparticles derived from phi29 motor pRNA:

(Nature Nanotechnology)

(ACS Nano) (Nano Today)

(RNA) (Nano Today)


Peixuan Guo and coworkers proved the concept of RNA Nanotchnology in 1998, published in Molecular Cell and featured by Cell in the same year. 

Discovery of a New Class of Biomotor with a Revolution Machenism (see movie)

Discovery of First Motor with Revolution Motion in a Virus-killing Bacteria Advances Nanotechnology [Youtube]

Biomotor and RNA Nanotechnology for Medical Applications [Youtube]