Center Director                                                                                   Advisory Board
                      

Peixuan Guo
Professor & Director of Center for
RNA Nanobiotechnology and Nanomedicine
College of Pharmacy & College of Medicine

Henry J. Mann
Dean and Professor
College of Pharmacy
Raphael Pollock
Director of The Ohio State
University Comprehensive
Cancer Center


Vision

The Center will serve as a platform for collaboration among the many investigators in the College of Pharmacy and existing centers across the OSU campus with research efforts in RNA nanobiotechnology and nanomedicine with international collaboration.

Cynthia A. Carnes
Senior Associate Dean
College of Pharmacy
Peter A. Mohler
Professor and Chair
Department of Physiology
and Cell Biology



 

Mission

The Center's cross-disciplinary research will achieve novel materials and innovative therapeutic strategies to treat indications with few effective treatment options such as cancer, obesity, diabetes, cardiovascular disease, lung disease, and drug abuse. The Center intends to transform basic science research in RNA nanotechnology and nanomedicine through innovative approaches to disease treatment and diagnostics, creating the next generation scientific workforce and launching small agile spin-off companies to pursue Center breakthroughs. The mission is well aligned with the College of Pharmacy's strategic plans to enhance visibility, to continue to build on drug discovery research, and to move new drugs to the clinic.

Membership of the Center

Full members:

Federica Accornero

Assistant Professor
College of Medicine
Nationwide Children's Hospital

Irina Artsimovitch

Professor
Department of Microbiology

Xue-Feng Bai

Associate Professor
College of Medicine

Sharyn Baker

Professor & Gertrude Parker Heer Chair
College of Pharmacy

Charles Bell

Associate Professor
College of Medicine

Dennis Bong

Professor
Department of Chemistry & Biochemistry

Michael Caligiuri
Director of the Comprehensive Cancer Center
College of Medicine

Cynthia A. Carnes

Senior Associate Dean
College of Pharmacy

William Carson

Director of Surgical Oncology Translational Research
College of Medicine


Emanuele Cocucci
Research Scientist
College of Medicine


Yizhou Dong

Assistant Professor
College of Pharmacy

Richard Fishel

Professor
College of Medicine

Sylvan G. Frank

Faculty Emeritus
College of Pharmacy

Deliang Guo

Associate Professor
College of Medicine

Peixuan Guo

Professor & Director of Center for RNA Nanobiotechnology and Nanomedicine
College of Pharmacy & College of Medicine

Rajgopal Govindarajan

Associate Professor
College of Pharmacy

Renzhi Han

Associate Professor
Wexner Medical Center

Xiaoming He

Associate Professor
College of Engineering

Krishan Kumar

Director of Laboratory for Translational Research in Imaging Pharmaceuticals
College of Medicine

Robert Lee

Professor
College of Pharmacy

Guoqiang Li

Associate Professor
College of Medicine

Wu Lu

Professor
College of Engineering

Jianjie Ma

Professor
College of Medicine

Henry J. Mann

Dean and Professor
College of Pharmacy

Peter A. Mohler
Professor and Chair
Department of Physiology and Cell Biology

Peter Shields

Deputy Director of the OSU
Comprehensive Cancer Center
College of Medicine

Dan Shu

Research Associate Professor
College of Pharmacy

Qi-En Wang

Associate Professor
Department of Radiology

Noah Weisleder

Associate Professor
College of Medicine

Jack Yalowich

Professor
Division of Pharmacology
College of Pharmacy

Jianhua Yu

Associate Professor
College of Medicine

Hua Zhu

Associate Professor
Department of Surgery, OSU Wexner Medical Center

Terence Williams

Associate Professor
Department of Radiation Oncology, OSU Wexner Medical Center

Carlo Croce

Professor and Chair
Department of Cancer Biology and Genetics, College of Medicine

Richard A. Lease

Research Scientist/Lab Supervisor
Dept. of Chemistry and Biochemistry & Dept. of Chemical and Biomolecular Engineering

 

Goals

Long term goals:

  1. Engage in fundamental research or applied research to create intellectual properties, high impact publications, and valuable patents.
  2. Successfully pursue the translation of fundamental research from the lab bench to the clinic and the market, using the created intellectual property to launch spin-off companies and attract high technology companies to the region.
  3. Generate royalty income to continue growth of the Center.
  4. Secure extramural funding to continue to support the Center's research efforts and allow the foundation to successfully compete for major extramural funding.


Short term goals:

  1. Establish a platform for exchange of ideas and develop a research plan based on the expertise of OSU members.
  2. Enhance communication and collaborative activity among OSU faculty interested in RNA nanotechnology and nanomedicine with the goal of building fruitful new relationships across disciplines.
  3. Enhance the training of graduate and postdoctoral students by in-reach and out-reach mechanisms for communicating OSU's growing nanobiotechnology research, such as organizing symposia in the individual relevant areas and establishing a seminar series. Lab training programs consisting of a mix of lectures, conception/design of research projects, and hands-on lab training designed to introduce participants to the working framework of nanobiotechnology will be offered, supported by tuition collected from the trainees and funding agencies, with the goal of promoting the fields pioneered by members of the Center.
  4. Build an infrastructure necessary for national and international recognition as a leading research center in nanobiotechnology by accepting international institution membership.
  5. Exchange graduate students, postdocs, and faculties (visiting scholars) among member institutes to help trainees rapidly advance their research projects, providing them with an opportunity to work with leading scientists and become part of an international network. The host institute will provide facilities and equipment, while the visiting institute will provide travel and support for room and board.

 

Rationale

Nanobiotechnology seeks to exploit recent advances in nanotechnology to address critical needs in medicine and the biological sciences. In particular, RNA nanotechnology has demonstrated significant potentials for developing RNA nanoparticles for in vivo drug delivery. To advance the field and international collaboration, these complex, large-scale scientific opportunities require cutting-edge interdisciplinary work by teams of researchers drawn from multiple disciplines and international collaboration. Important examples include, but are not limited to, more effective therapies for cancer, obesity, cardiovascular system, infectious disease, drug abuse, drug resistant, innovative diagnostics, early detection of diseases, and the use of RNA as anion polymer for material science, imaging reagents, optical equipments, and computer modules.

These opportunities can be seized by world-class research teams when the challenges of assembling and fielding interdisciplinary teams are successfully met. These challenges include connecting and integrating researchers in teams across many different disciplines; enabling communication between the different cultures of medicine, natural science and biomedical engineering; building relationships to establish the essential trust at the basis of all collaboration; and managing effectively without creating bureaucratic obstacles that slow activity. All of these call for innovative approaches.

Responding to the opportunity and addressing these challenges, the OSU Center of RNA Nanobiotechnology and Nanomedicine will be established as an innovative platform for a flexible and agile center providing unique contributions, functioning as a node linking many researchers across multiple networks and as a matrix from which to create both new interdisciplinary research collaborations and the next generation scientific workforce in nanoscience and technology. The center will leverage already established but dispersed OSU biomedical research efforts, using nanobiotechnology as a multidisciplinary focal point to integrate these efforts for maximum impact. The proposed Center will build upon effective collaborations located within the campus including the James Comprehensive Cancer Center, Center for RNA Biology, Center for Brain and Spinal Cord Repair, Center for Clinical and Translational Science, and Center for Retrovirus Research.

 

Application Procedure and membership qualifications

To apply for membership, faculty must submit a completed application form and a current CV and is nominated by at least one of the center members. Three levels of membership will be offered:

  1. Full Membership: Tenured track or Tenured Faculties fulfilling at least two of the following four requirements: (a) have active federal/state grants; (b) have Pubmed publications during the last five years involving nanobiotechnology, such as nanoscale biomaterials, nanomedicine, nanobiomechanics, nanophotonics, single molecular imaging, etc; (c) currently have graduate and/or postdoctoral students; (d) demonstrating strong interest in nanobiotechnology or RNA nanobiotechnology as showed by active interaction with current center members.
  2. Associate Membership: No specific requirements, but a strong interest to engage in nanobiotechnology research and nanomedicine involving RNA.
  3. Institution membership:
In all, Membership is free. The only stipulation is that the PI must have sufficient resources (funding support, physical lab space, facilities, equipment, and research staff) to conduct projects related to nanobiotechnology.

 

Description of faculty involvement

Faculty will be involved in Center activities in numerous ways:

  1. Members will be eligible for the participation of (a) center committees, (b) training class conducted by the center, (c) free registration for conferences sponsored by the center, (d) serving as PI, co-PI, multi-PI or collaborators, collaboration on center grant proposals, (e) coauthor in center publications by demonstration of participation, (f) free to center workshops, retreats, (g) nomination of center seminar speakers, (h) serving as advisor for center graduate students.
  2. Faculty will be critical knowledge experts in diverse research areas, including but not limited to: (1) RNA nanotechnology; (2) Nanopore sensing and early disease diagnosis; (3) Drug transporters and Nanotechnology; (4) Cancer Nanobiotechnology; (5) Liposomes as a nanodelivery system; (6) Micelles as nanodrugs; (7) Nanosynthetic chemistry; (8) Synthetic Biology; (9) Nanoimmunology; (10) Single molecule instrumentation; (11) Nanotechnology for therapy of cancer or viral diseases; and (12) Drug development.
  3. Investigators in research to foster sustainable development of the Center through research grants and outreach efforts.
  4. Collaborators with partners to transform research from the bench to the clinic/industry.

Affiliate national or international institution membership

The institute will be 1) eligible for faculty and student exchange for RNA nanobiotechnology and nanomedicine. The accepting institute will offer research facilities and resources, the dispatching institute will be responsible for the cost of the travel, room and board, and medical insurance of the exchanged faculty. 2) Eligible to sponsor or participate in a training class of RNA nanobiotechnology and nanomedicine.

 

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