Peixuan Guo


Dr. Peixuan Guo Fellow of the National Academy of Inventors (NAI); Editor in Chief for RNA NanoMed journal; Sylvan G. Frank Endowed Chair in Pharmaceutics and Drug Delivery Systems; Director of Center for RNA Nanobiotechnology and Nanomedicine; President of International Society of RNA Nanotechnology and Nanomedicine; Professor of College of Pharmacy and College of Medicine; Former Director, NIH Nanomedicine Development Center
Biosketch Dr. Guo, a fellow of the National Academy of Inventors, and a pioneer of RNA nanotechnology and has held three endowed chair positions at three different prestigious universities. He is currently Endowed Chair professor in COP/OSU, the OSU director of Center for RNA Nanobiotechnology and Nanodicine, the President of the International Society of RNA Nanotechnology and Nanomedicine (ISRNN); the Editor-in-Chief of RNA NanoMed, and the chairman of 13 international conference including the in incoming NIH funded Dec/2025 RNA/Exosome conference in LA, one symposium of the Biophysics Society Annual Meeting Feb 2026, and the founding chair of the 2015 Gordon Research Conference in RNA Nanotechnology. He received his Ph.D. from U Minnesota under Dwight Anderson and postdoctoral training at NIH/NIAID under Bernard Moss, a pioneer of vaccinia virus as vaccine vector and a fellow of the National Academy of Sciences. Dr. Guo has been a Young Distinguished Faculty Scholar of Purdue University, where he was a director of the NIH Nanomedicine Development Center (NDC). He proved the concept of RNA Nanotechnology in 1998.  He constructed a first biomotor that can package dsDNA in the test tube; assembled a first infectious dsDNA virus using all purified components; discovered a New Class of Biomotor with a Revolution Mechanism; inserted a viral motor channel into membrane for single molecule sensing of dsDNA, RNA, peptides and chemicals(Link); discovered that RNA nanoparticles are motile and deformative, leading to spontaneous cancer targeting without detectable toxicity; decorated exosome with RNA ligand for cell targeting. Dr. Guo has received many honors, including the most recent “Innovator of the Year” by OSU in 2021, and the OSU President's Research Excellence Catalyst Award in 2024, and has been supported by NIH with many grants for many years. He is a member of many federal programs, including the Federal five-year, 10-year, and 15-year Nanobiotechnology Strategy Plan organized by NIH, NSF, NIST, and the Federal Committee of Science and Technology. Research Interest 1. Nanobiotechnology, including structure, function and applications of phi29 DNA-packaging nanomotor. 2. RNA Nanotechnology and siRNA/drug delivery. 3. Single molecule imaging and optical instrumentation to study the nanomotor and RNA nanoparticles. 4. Single pore sensing and singe pore DNA sequencing using the connector of phi29 DNA packaging motor.
Contact Information: Mailing Address: OSU BRT, 460 W 12th Ave., Columbus, OH 43210, USA Email: guo20@osumc.edu; Phone: (614)293-2114 (Office), (614)293-2188 (Lab)